In Chap. 1 , the history of cognitive-behavioral therapy (CBT) with Black Americans was discussed. Chapter 2 identified structural factors which influence micro-level psychotherapeutic processes in CBT. The present chapter identifies and explains the ten cognitive-behavioral principles that are of relevance for Black Americans. These ten cognitive-behavioral principles are substantiated by basic and applied research that intersect CBT and Black American culture and history. The ten principles are also substantiated by historical and contemporary structural, intrapersonal, and interpersonal factors which influence the implementation of CBT with Black Americans. For each principle, a definition is provided, and the principle’s relevant functions for the cognitive-behavioral clinician are described. This chapter concludes with a theoretical overview of the specific groups of Black Americans who may be particularly appropriate candidates for the ten cognitive-behavioral principles.