As life expectancy increases and people’s lifestyles improve, there is a growing concern for health, which includes preventing disease and improving physical appearance. Consumers are increasingly aware of the benefits of using natural ingredients in healthcare products, including cosmetics and food supplements. Marine compounds in particular are emerging as a new source of active ingredients due to their antioxidant, anti-inflammatory, antiaging, and nutritional properties. However, some of these compounds are of limited use due to their lipophilicity, and solutions need to be found to overcome this drawback. In this context, the use of lipid nanoparticles, such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), is gaining attention due to their ability to protect and promote the absorption of lipophilic molecules. Indeed, there are a number of studies demonstrating the efficacy of encapsulating these compounds and applying them to healthcare products. However, as this is a new field, there is still no global legislation on the use of lipid nanoparticles in health products, and safety concerns have been raised regarding their use, which should be addressed through further animal and human studies. This chapter focuses on the use of lipophilic bioactive compounds of marine origin in health products and their encapsulation in SLN and NLC. The first sections present examples of these compounds and their respective applications in cosmetics and food supplements. Next, some limitations of these applications are mentioned, and SLN and NLC are presented as a promising alternative to overcome these problems. Finally, regulatory and safety issues related to their use are discussed.