Access to appropriate mobility aids is crucial for individuals with locomotor impairments, yet many in India lack access to well-fitted assistive devices. This study evaluates the long-term impact of customized wheelchairs on mobility, independence, and overall quality of life. A longitudinal study was conducted with 43 participants, assessing outcomes three months and two years after receiving customized wheelchairs. Data were collected using the WHOQOL, FEW, and PIADS scales, with paired t-tests performed to determine statistical significance. Results indicate sustained improvements in mobility, psychosocial well-being, and daily functioning, with a 12.5% increase in FEW scores and notable gains in quality of life and independence. Despite these benefits, challenges such as accessibility to repairs and affordability persist. The findings highlight the need for better support structures, including repair services, peer mentorship programs, and policy initiatives to enhance affordability. Addressing these barriers could ensure that individuals with disabilities experience long-term benefits from customized mobility solutions, ultimately fostering greater independence and inclusion.