Sepsis remains a leading cause of morbidity and mortality worldwide, requiring a structured, multidisciplinary approach to prevention, early detection, and intervention. This chapter explores the sepsis care continuum, emphasizing the crucial role of nurses in early warning detection, prevention strategies, and post-sepsis care. While sepsis can arise from various infections, bloodstream infections (BSIs) are a significant and preventable contributor. Healthcare-associated BSIs, such as catheter-related infections and secondary BSIs from pneumonia or urinary tract infections, can escalate into sepsis if not promptly detected and treated. Preventing these infections is crucial to reducing sepsis cases. Beyond prevention, early detection is essential. The Early Warning Score (EWS) and Nurse Intuition Patient Deterioration Score (NIPDS), combined with rapid response protocols improve healthcare workers ability to identify patients at risk and prevent progression to severe sepsis. Sepsis prediction models in emergency and primary care are promising advancements. Their development could enhance early diagnosis and reduce in-hospital mortality. Post-sepsis, survivors often face long-term impairments, necessitating structured rehabilitation. Strengthening frameworks and interdisciplinary collaboration ensures effective sepsis management, patient safety, and recovery. Nurses and infection prevention and control (IPC) teams have a key role in translating these strategies into practice.