A pivotal element of the transformation strategy involves embedding autonomic technologies into the core of the business and promoting collaboration between technology and business teams. As AI agents usher in autonomic business, organizations will evolve into AI–human hybrid environments. In these settings, a substantial portion of marketing, sales, operations, and other domains will be driven by machine-based decisions and workflows, with humans taking on roles of oversight and monitoring. This ensures fallback mechanisms are in place, given the complexity of self-managing and self-adaptive systems. We explore the organizational implications of autonomic business across different phases of maturity, how to reshape the executive team to respond to the new challenges and offer a template for creating a transformation blueprint.