Traumatic colon injury may occur as a result of blunt or penetrating mechanism and is associated with significant morbidity and mortality. In this chapter, we will review the epidemiology, pathophysiology, anatomy and embryology, classification, operative management, and morbidity and mortality associated with traumatic colon injury. This chapter will review both historical perspectives and contemporary approaches to the evaluation and management of traumatic colon injuries, particularly as data has emerged challenging the traditional mandates of fecal diversion.