In this study we analyze the effects of what we define “anytime & anywhere availability” (AAA), which is referred to the condition brought by technological advancement and in particular work activities carried out remotely, thanks to the actual technological devices and smartphones, away from dedicated workstations which often result on working beyond pre-established times and inability to break away and rest from work anywhere. The following qualitative study performed in various organizations explores the negative effects of this condition and reveals the crucial role played by sense of responsibility. Implications of the study are particularly relevant for both Human Resources departments to enhance efficiency in their organizational contexts and researchers who want to further understand determinants and effects of new work modalities. Also, the results of the study can be adopted by policy makers to design laws and guidelines that help organizations rethink their workplaces safety policies.