Both internal and external elements have a strong influence on the aging process. Delays in wound healing, increased skin fragility, and slower turnover are all consequences of thinning skin layers that occur with age. Decreased expression of collagen and other proteins that promote structure and volume is linked to a dermal-epidermal interface that is becoming weaker. Radiation, overall health, alcohol and cigarette consumption, and gravity are some external elements that can influence these fundamental processes. Loss of skin elasticity, soft tissue fall, muscular atrophy, and bone loss are all results of the aging process, which is influenced by internal and external influences. Excess skin on the lower face can cause jowling, and bone loss along the mandible can limit the chin projection. The drooping of soft tissues that causes a noticeable submental crease is the root cause of chin ptosis, or witch’s chin. Facial rejuvenation includes measures to lessen the visible signs of aging on the chin and mandible. This chapter aims to examine the most popular dermal fillers, emphasizing their safety and effectiveness, mechanism of action, indication, technique, and data supporting their use as a nonsurgical method for mandibular rejuvenation. To help clinicians choose the best option for their patients’ aesthetic goals, it is important to understand the pros and cons of injectable fillers for jawline rejuvenation.