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Skin barrier alterations play an etiological role in the development of irritant contact dermatitis (ICD). Various skin irritants, including detergents, wet work, and organic solvents, can induce a wide range of skin barrier alterations. These alterations are influenced by the intrinsic properties of the irritants, as well as by exposure conditions and individual host-related factors. In this chapter, we will address the mechanisms by which common skin irritants impact skin barrier function at both the molecular and morphological levels.

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Effects of Irritants on the Skin Barrier Morphology and Function

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  • 发表日期：

    2025年

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  • Suzana Ljubojevic Hadzavdic,
  • Ana Bošnjak,
  • Daška Štulhofer Buzina,
  • Ivone Jakasa

摘要

Skin barrier alterations play an etiological role in the development of irritant contact dermatitis (ICD). Various skin irritants, including detergents, wet work, and organic solvents, can induce a wide range of skin barrier alterations. These alterations are influenced by the intrinsic properties of the irritants, as well as by exposure conditions and individual host-related factors. In this chapter, we will address the mechanisms by which common skin irritants impact skin barrier function at both the molecular and morphological levels.