Arsenic contamination in drinking water poses a significant public health risk, particularly in regions with high levels of natural arsenic. Implementing effective arsenic removal technologies is crucial to mitigate these risks. This chapter explores the multifaceted challenges and opportunities associated with the deployment of arsenic remediation technologies. The challenges encompass technical, economic, and sociocultural dimensions. Technical hurdles include variability in arsenic speciation and concentration, the presence of co-contaminants, and the need for low-cost, low-maintenance solutions suitable for rural and resource-limited settings. Economic challenges include the high initial costs of technology installation, ongoing maintenance expenses, and limited financial resources in affected communities. Sociocultural challenges highlight the need for community involvement, education, and adaptation of technologies to local contexts and preferences. Conversely, opportunities in this field are driven by advances in technology, such as the development of novel adsorbent materials and point-of-use systems, increased global awareness, and funding initiatives. Collaborative efforts between governments, nonprofits, and the private sector are critical to scaling successful implementations. By addressing these challenges and leveraging opportunities, sustainable arsenic mitigation can be achieved, improving public health outcomes and ensuring access to safe drinking water for affected populations.