Unlike weaning from invasive MV, weaning from NIV still lacks studies to support standardization of the best protocol. Prolonged use of NIV may prolong hospital stays, increase the risk of hospital-acquired infections, and increase overall costs; on the other hand, premature weaning from NIV may worsen the patient’s clinical condition and increase the likelihood of intubation. Three main types of protocols for weaning patients from NIV have been reported: immediate weaning, stepwise pressure reduction, and stepwise duration reduction. It is unclear which method is best, but if there is not a high number of comorbidities associated with respiratory failure and the condition resolves in a short time, the patient can be immediately weaned from NIV; if there is an unfavorable clinical condition, more precise monitoring and the use of a gradual weaning protocol are required.