The African Continental Free Trade Area (AfCFTA) creates a transformative opportunity for African countries to strengthen economic integration and foster intra-African trade. Regulatory cooperation emerges as an essential aspect to ensure the effectiveness of the AfCFTA. This chapter explores the importance of regulatory cooperation in promoting market integration and efficient continental free trade. In light of this chapter, regulatory cooperation entails collaborative regulatory measures among member states to establish and align regulatory frameworks, best practices and international standards to govern the African continental trade area. Such cooperation is essential for eliminating unnecessary barriers, increased competitiveness, protection of consumer rights, promoting information sharing, reducing trade costs and fostering a conducive environment for business through mutual recognition, harmonization and convergence of regulations. However, the chapter also acknowledges the challenges associated with implementing regulatory cooperation mechanisms. For example, differing regulatory philosophies, institutional capacities and political dynamics. The authors propose collaborated dispute resolution mechanisms and phased regulatory approaches to ensure the implementation of a robust intra-African trade regulatory framework. The chapter underscores the importance of proactive collaboration, information sharing and ongoing dialogue to enhance regulatory cooperation within the AfCFTA so as to maximize its benefits for all stakeholders.