Plants face various environmental biotic or abiotic stressors, challenging their growth and development. Abiotic stresses such as salinity inhibit the physiological and morphological processes of the plants. Despite these limitations, plants can counteract the consequences of stress by producing the necessary physiological, biochemical, or molecular responses. Plants might achieve this by regulating the expression of genes involved in tolerance mechanisms through transcription factors (TFs). They can modulate salt uptake or transport, production of osmolytes, ion homeostasis, and Na+/K+ ratios by binding the downstream target genes. Furthermore, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are also crucial elements of salinity tolerance in plants. Through the direct degradation of mRNA or the inhibition of its translation into protein, miRNAs enable the quick post-transcriptional modification of stress-responsive gene expression. On the other hand, lncRNAs enable the transcriptional or epigenetic modification of the genes involved in salt stress tolerance. All of these regulatory networks and intrinsic mechanisms enhance plant tolerance to salinity and also represent possible phytoremediation strategies. Therefore, it is essential to understand the molecular processes underlying plant tolerance against salinity.