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Acute and chronic kidney diseases have profound effects on multiple organ systems, including the central nervous system (CNS). Emerging evidence highlights a bidirectional interaction between the brain and kidneys, mediated by neural circuits, humoral factors, and inflammatory pathways. This review explores the mechanisms underlying brain-kidney crosstalk, focusing on autonomic dysregulation, neuroinflammation, and shared pathophysiological pathways in acute kidney injury (AKI) and acute brain injury (ABI). Understanding these interactions is crucial for developing neuroprotective and reno-protective strategies in critically ill patients.

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Renal Disease and Neural Circuits: Brain-Kidney Crosstalk

  • 章节

  • 发表日期：

    2025年

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  • Lilia Rizo-Topete,
  • Gonzalo Ramírez-Guerrero,
  • Cristian Pedreros-Rosales

摘要

Acute and chronic kidney diseases have profound effects on multiple organ systems, including the central nervous system (CNS). Emerging evidence highlights a bidirectional interaction between the brain and kidneys, mediated by neural circuits, humoral factors, and inflammatory pathways. This review explores the mechanisms underlying brain-kidney crosstalk, focusing on autonomic dysregulation, neuroinflammation, and shared pathophysiological pathways in acute kidney injury (AKI) and acute brain injury (ABI). Understanding these interactions is crucial for developing neuroprotective and reno-protective strategies in critically ill patients.