Building truly innovative organizations requires strong leadership and powerful innovation teams, along with a genuine culture of innovation that enables them to thrive. This chapter addresses organizational design and leadership questions, presenting strategies on “who should be leading innovation within the company” and providing a thorough framing of the chief innovation officer role. It explains what makes exceptional innovators and how to assemble cross-disciplinary innovation “dream teams” and emphasizes the importance of a healthy innovation culture that unites people through shared values of trust, safety, openness, purposefulness, curiosity, and healthy competition. The chapter identifies common cultural blockers that prevent employee engagement with innovation and provides practical guidance for bootstrapping cultural transformation through targeted improvements that address key blockers, such as bureaucracy and communication gaps.