Melanoma and non-melanoma skin cancers are one of the most common cancers prevalent in white-skinned populations, and its rising incidence and mortality associated with it have generated a significant need for preventative strategies. Approximately, more than 100,000 cases of melanoma and 3,000,000 cases of non-melanoma skin cancer occur globally each year. Ultraviolet radiation exposure is a major risk factor for the development of skin cancers, and increased incidences of development of skin cancers and their precursors have been reported with the use of non-solar radiations such as sunlamps and tanning beds. Campaigns are being implemented by dermatologists worldwide that focus on patient education and promote behavioral modification aiming at primary and secondary prevention of skin cancers. Early detection and evidence-based screening of skin cancer through conventional methods and breakthrough technologies are critical for improving treatment outcomes and reducing mortality.