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Over half a century after the first use of Bacillus Calmette-Guérin (BCG) on bladder cancer treatment by Morales et al., BCG is still the standard of care for high-risk non-muscle invasive bladder cancer (NMIBC) and the most successful example of vaccine against cancer. In this chapter, we describe the origin of BCG, its effect on bladder cancer and the immune system, and the non-specific protective effect of BCG vaccine on viral infections and other forms of cancer.

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BCG Immunotherapy: Old Tool and New Concepts

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  • 发表日期：

    2025年

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  • Mehrsa Jalalizadeh,
  • Luciana S. B. Dal Col,
  • Reza Yadollahvandmiandoab,
  • Leonardo Oliveira Reis

摘要

Over half a century after the first use of Bacillus Calmette-Guérin (BCG) on bladder cancer treatment by Morales et al., BCG is still the standard of care for high-risk non-muscle invasive bladder cancer (NMIBC) and the most successful example of vaccine against cancer. In this chapter, we describe the origin of BCG, its effect on bladder cancer and the immune system, and the non-specific protective effect of BCG vaccine on viral infections and other forms of cancer.