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The last decade has seen an exponential rise in the use of immune checkpoint inhibitors (ICIs). The use of ICIs has given new hope in cancer treatment. At the same time, there are unique side effects related to ICIs which pose a challenge to practicing oncologists. The international societies have laid down recommendations to assist in managing these adverse events (AEs). Among the immune-related adverse events (irAEs), the nervous system is one of the rare sites to be affected. Due to the rarity of irAEs, there is little practical experience among the oncologists. This chapter is a comprehensive review of the neurological irAEs, their clinical presentation, and management.

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A Review of Neurotoxicities Associated with Immune Checkpoint Inhibitors

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  • 发表日期：

    2025年

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  • Kamal Kant Sahu,
  • Nicolas Sayegh,
  • Haoran Li

摘要

The last decade has seen an exponential rise in the use of immune checkpoint inhibitors (ICIs). The use of ICIs has given new hope in cancer treatment. At the same time, there are unique side effects related to ICIs which pose a challenge to practicing oncologists. The international societies have laid down recommendations to assist in managing these adverse events (AEs). Among the immune-related adverse events (irAEs), the nervous system is one of the rare sites to be affected. Due to the rarity of irAEs, there is little practical experience among the oncologists. This chapter is a comprehensive review of the neurological irAEs, their clinical presentation, and management.