Mindfulness is often associated with meditation. This chapter presents a distinction between meditation-based mindfulness and Langerian mindfulness. Focusing on Langerian mindfulness as a distinct mode of mindfulness, this article argues how Langerian mindfulness may be used in clinical hypnosis to develop a more radical transformation of consciousness. While meditation-based mindfulness plays a significant role in espousing specific modes of mind that are prone to tranquility, calmness, and equanimity, Langerian mindfulness develops a creative state of mind that is also flexibly tailored toward a peace-oriented mentality with potential features for a foundational change in one’s psychological being. This chapter explores how Langerian mindfulness may facilitate the process of implementing clinical hypnosis.