This chapter explores psychosocial interventions for individuals experiencing homelessness, emphasizing their potential effectiveness despite implementation challenges. It critiques the assumption that psychotherapy is not feasible in this population and outlines alternative models including brief, opportunistic, and psychotherapeutically informed approaches. Key interventions include motivational interviewing, which shows modest benefits for substance use, health service engagement, and housing retention; and logotherapy, which fosters hope and meaning through values-based work. The chapter addresses the central role of trauma therapy—especially Narrative Exposure Therapy—for individuals with complex PTSD and examines the debate around phased treatment approaches. Cognitive behavioral strategies such as problem-solving and SMART goal setting are advocated as core clinician skills. Contingency management, though ethically complex, demonstrates improved outcomes in targeted behavior change when financial or material incentives are used. The Housing First model is evaluated, with evidence supporting housing stability but limited impact on psychiatric or substance outcomes, highlighting the need for trauma-informed, flexible support. Transitional care during hospital discharge is identified as a critical intervention point, and the chapter concludes by emphasizing the importance of structured, respectful endings in therapeutic relationships. Overall, the chapter advocates for flexible, evidence-informed psychosocial strategies that meet individuals where they are and address the broader social determinants of health.