Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder that occurs in approximately 6–20% of women of reproductive age. Most of the symptoms of PCOS manifest early during puberty. The most accepted diagnostic criterion is the Rotterdam criterion, which includes two of the last three characteristics: hyperandrogenism, oligo- or an-ovulation, and polycystic ovaries. The persistent hormonal imbalance leads to the formation of multiple small antral follicles and an irregular menstrual cycle, causing infertility and HSDD. Additionally, cardiovascular diseases, abdominal obesity, psychological disorders, infertility, and cancer are related to PCOS. Hyperandrogenism then causes insulin resistance and hyperglycemia, leading to the formation of reactive oxygen species (ROS), oxidative stress, and abdominal adiposity. Consequently, there is also an increase in inflammation, ROS production, insulin resistance, and hyperandrogenemia (Siddiqui et al., J Assist Reprod Genet. 39:2439–2473, 2022). Although the etiology of this disorder is not clear, environmental and genetic factors are mainly involved. Physical inactivity, as well as poor eating habits, play a key role in the progression of PCOS. The initiation of antiandrogen treatment at an early age (≤25 years) could be helpful in spontaneous conception in women with PCOS.