Many uncertainties about the differences between men and women in many aspects of sexual life remain to be understood. One of these is compulsive sexual behavior disorder, which continues to be more frequent in men, although neuroticism and vulnerability to stress are to be reported more frequently in women. But not least, hypoactive sexual desire disorder—in men and women. Further scientific research is increasingly necessary to deeply understand not only the differences but also the best approaches to overcome these disorders when they constitute barriers to understanding and enjoying the sexual experience.