Cholesterol is an important fat found in blood that is involved in the development of heart disease. It comes in many forms, including low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides. LDL, also called “bad cholesterol,” contributes to the buildup of plaque in arteries. HDL, “good cholesterol,” helps remove excess fat from blood vessels and lowers disease risk. Targeted treatments like statins help lower bad cholesterol levels in the blood and are cardioprotective. PCSK9 inhibitors, bile acid resins, and fish oils are other available options to help achieve optimal cholesterol levels. Reaching your target cholesterol level with a drug takes time, so it is important to stay informed about your numbers and to engage in healthy lifestyle practices in addition to medical therapy.