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A 59-year-old female with a clinical history (4 years) of mild cognitive impairment with long-term (episodic and autobiographic) and short-term memory deficits worsened in the last 2 years. A [18F]FDG PET/MR showed a pattern that could be associated with a diagnosis within the Alzheimer’s continuum; however, a CSF analysis was negative for cerebral amyloidosis. [18F]Florbetaben (90–110 min after injection) amyloid scan revealed diffuse bilateral cortical and subcortical uptake of the radiopharmaceutical.

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Case 7: Typical AD with Discordant Biomarkers

  • 章节

  • 发表日期：

    2025年

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  • Diego Cecchin,
  • Annachiara Cagnin,
  • Mariagiulia Anglani

摘要

A 59-year-old female with a clinical history (4 years) of mild cognitive impairment with long-term (episodic and autobiographic) and short-term memory deficits worsened in the last 2 years. A [18F]FDG PET/MR showed a pattern that could be associated with a diagnosis within the Alzheimer’s continuum; however, a CSF analysis was negative for cerebral amyloidosis. [18F]Florbetaben (90–110 min after injection) amyloid scan revealed diffuse bilateral cortical and subcortical uptake of the radiopharmaceutical.