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A 67-year-old man, with no history of neuromuscular disorders, came for evaluation of progressive weakness in his left arm. [18F]FDG PET-MRI highlights the presence of a moderate hypometabolism localized at the right precentral gyrus, suggesting a selective degeneration of neurons of the primary motor area. Final diagnosis was amyotrophic lateral sclerosis with additional features, consistent with ALS-plus syndrome.

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Case 12: Atypical Upper Motor Neuron Disease

  • 章节

  • 发表日期：

    2025年

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  • Diego Cecchin,
  • Gianni Sorarù,
  • Mariagiulia Anglani

摘要

A 67-year-old man, with no history of neuromuscular disorders, came for evaluation of progressive weakness in his left arm. [18F]FDG PET-MRI highlights the presence of a moderate hypometabolism localized at the right precentral gyrus, suggesting a selective degeneration of neurons of the primary motor area. Final diagnosis was amyotrophic lateral sclerosis with additional features, consistent with ALS-plus syndrome.