This study examines the relationship between threat (perceived vulnerability and perceived severity) and coping appraisal (self-efficacy and response efficacy) with ostracizing behavior at the workplace due to health protection measures from infectious diseases. Data was collected from 149 back-end employees in eight targeted local commercial banks in Kuala Lumpur and analyzed using Partial Least Square Structural Equation Modeling (PLS-SEM). The findings reveal that perceived vulnerability, perceived severity, and self-efficacy have a positive relationship with ostracizing behavior, while response efficacy has a negative relationship with ostracizing behavior at the workplace. However, the study has several limitations: it only explores specific types of ostracism at the workplace, data collection during the shift from the COVID-19 pandemic to the endemic phase may have influenced results, and the focus on the banking sector is not broadly applicable to other sectors. Despite these limitations, the present study is one of the first empirical studies to show ostracizing behavior at the workplace due to health protection measures from infectious diseases.