Achieving greater environmental sustainability and reducing CO2 emissions requires innovative approaches to energy management, especially in institutions like universities that operate complex energy systems. This chapter aims to provide a detailed analysis of the University of Passau’s strategy for increasing the sustainability of its campus, with a focus on the concept of an energy cell—a localized, self-sufficient energy system that integrates electricity, heating, and cooling. This chapter presents a case study for the University of Passau that reviews past and current activities, such as the long-standing use of waste heat recovery and sector coupling between heating and cooling, while highlighting the next critical steps, particularly in the electricity sector. By expanding photovoltaic power generation and unlocking flexibility potentials through the use of AI-driven data centers and thermal storage systems, the university is working toward a high degree of self-sufficiency and self-consumption. This chapter discusses the challenges posed by the variability of renewable energy sources and presents the measures being implemented to balance supply and demand on various time scales. The findings offer valuable insights for other institutions aiming to reduce their carbon footprint while managing the complexities of integrated energy systems.