Since the Food and Drug Administration (FDA) initially released the safety communication regarding transvaginal mesh used for prolapse repair in 2008, the focus on complications related to transvaginal mesh has been heightened. Various complications can occur after transvaginal mesh is placed for either stress incontinence or pelvic prolapse; however, persistent pain after mesh placement for stress urinary incontinence (SUI) and pelvic prolapse, including vaginal pain, dyspareunia, suprapubic pain, and thigh pain, can incur significant morbidity for the patient. Evaluation and treatment options are reviewed.