Virtual reality (VR) games offer innovative possibilities for promoting health, education, and inclusion in disability care. This chapter explores how VR gaming leverages neuroplasticity to drive cognitive, motor, and emotional improvements, highlighting its therapeutic potential for individuals with disabilities. It examines the role of engagement, motivation, and adaptive gameplay in making rehabilitation more accessible and enjoyable, while emphasizing the growing importance of digital biomarkers in monitoring therapeutic outcomes. Furthermore, it discusses how VR gamification can enhance mental health by reducing stress, fostering emotional resilience, and mitigating social isolation. By integrating neuroscience, motivational strategies, and inclusive design, VR games emerge as powerful tools for advancing health promotion and education for people with disabilities. Future directions call for deeper personalization, advanced technologies, long-term engagement strategies, and inclusive social features to maximize the impact of adapted games.