To improve the transmission quality of ocean buoy data and reduce the risk of data distortion and loss, research has been conducted on anti-interference transmission methods for ocean buoy data based on multiple sensors. Firstly, select appropriate sensors, configure sensor parameters, and use sensors to obtain data; Secondly, the collected multi-sensor data is fused to provide more accurate and comprehensive information than a single sensor; On this basis, develop an interactive protocol for the transmission and reception of ocean buoy data; Finally, design the transmission layer for ocean buoy data to achieve anti-interference transmission goals. The experimental results show that the average data transmission delay of the studied transmission method is always lower than that of the control group under different packet sizes, and the transmission success rate remains above 98%. Therefore, it indicates that the research method can effectively reduce latency and improve the reliability and real-time performance of data transmission.