Before the “Scramble for Africa,” when the major European countries formally divided Africa, African economies thrived in many spheres, especially trade. In today’s times, Africa is faced with difficulties of the 21st century that encompass health challenges, poverty, resource exploitation, and climate change. There is a dearth of research on factors that promote and impede the adoption of M-Health in developing nations. This review study explores the mobile health (M-health) role in sub-Saharan Africa’s (SSA) fight against diseases and future pandemics. M-health has the potential to improve healthcare service delivery for numerous health conditions. M-health enables effective use of real-time data to prevent and manage epidemics and illnesses. In contrast to the rest of the globe, SSA confronts unique challenges in the deployment, uptake, and growth of M-health systems. Awareness and sensitivity regarding outbreaks such as Ebola, COVID-19, and potential future pandemics must be enhanced, and individuals should be informed about the importance of self-care through suitable preventive actions. Recent epidemics, like severe acute respiratory syndrome (SARS), swine flu (H1N1), COVID- 19 and Ebola have given policymakers and stakeholders useful insights into the use of mobile health during public health crises. These lessons can lead to the development of innovative, more efficient technology to assist health risk authorities in dealing with the COVID-19 outbreak as well as future epidemics and pandemics.