This chapter locates Uzalo: Blood is Forever as a programming milestone in 50 years of television broadcasting in South Africa. Uzalo premiered on 9 February 2015, centring on two competing family dynasties in the north Durban township of KwaMashu, KwaZulu-Natal. The soap opera departed from the generic national identity, glamorised city setting and multiculturalism showcased in previous South African soap operas with its gritty township aesthetic and distinct portrayal of Zulu cultural identity (‘Zuluness’). In season two, the matriarchs ascended to the helm of their respective dynasties, promoting the view advanced by seminal scholars (Modleski, Film Quarterly, 33(1), 12–21, 1979; Hobson, Crossroads: The drama of a soap opera. Methuen eBooks, 1982; Brown, Australian Journal of Cultural Studies, 4(2), 1–25, 1987) that the soap opera genre advances a feminine discourse. This chapter examined the complexity of constructing an African feminine discourse in the characterisation of the matriarchal characters within a multicultural context. Data was extracted from interviews conducted with the producers and lead female characters of the show (Onuh, Representation of the matriarch in South African soap opera: a case study of Uzalo. University of KwaZulu-Natal, 2017), as well as a textual analysis of the female characters in season two (Landers, When myth becomes meaning: Examining the representation of female character construction in Uzalo: Blood is forever. University of KwaZulu-Natal, 2018). Additionally, the chapter provided commentary on Uzalo as an exemplar of the soap opera genre to adapt to shifting concerns of politics, economics, culture and gendered identities within the national and historical progression of broadcasting in South Africa.