Artificial Intelligence (AI) becomes continuously more implanted in various forms in business processes and organizational activities, revolutionizing the way organizations operate and manage their operations. One of the most significant impacts of AI is its integration in knowledge management that holds a vast potential by leading significant advancements in the way organizations collect, store, share, and strategically manage information to achieve their business objectives. In this context, the purpose of this work is to examine the impact of artificial intelligence on knowledge management and its elements in small- and medium-sized enterprises in Morocco. The study uses quantitative research, where 200 responses are collected to gather the required data for testing the hypotheses of the study. The results have revealed that adopting AI in small and medium enterprises is significant for the organizations to accelerate the adoption of a knowledge management solution, improve the connection of employees, and give them access to necessary resources to perform their tasks efficiently. Finally, it is noted that knowledge management system enhanced by artificial intelligence is the most effective solution.