The use of radiotracer techniques is well-established as a valuable tool for troubleshooting and process optimizationProcess optimization in various industries that rely on solution or pulp distributionDistribution systems. Industrial radiotracers have proven to be highly useful for examining and verifying the condition of several mineral processingMineral Processing systems in areas such as comminution, flotationFlotation, and leachingLeaching, as well as in the characterization of water management systems. One of the most well-known applications is the determination of residence time distributionDistribution through the online monitoring of a radioactive tracer. This technique allows for the assessment of several characteristics of the reactor’s performancePerformance using a combination of modelingModeling and analysisAnalysis of the measured variables. Additionally, the technique can be used for characterizing flow distributionsDistribution in solution or pulp systems, calibrating flow measurement devices in a non-invasive manner, and characterizing flow patterns in metallurgical reactors. In this article, several applications of radioactive tracers in large-scale industrial mining operationsMining operations, both in mineral processingMineral Processing and hydrometallurgical processingProcessing, are described, underscoring the versatility and necessity of tracer techniques in miningMining industries, highlighting their role in optimizing processes, ensuring safetySafety, and improving overall performancePerformance.