Extended depth-of-focus (EDOF) optical profiles are a group of optical designs that currently constitute an attractive alternative to multifocal intraocular lenses (IOL) designs. Currently several optical principles might be classified in five types based on the optical mechanism. These five types are based on the optical principle in which they are fundamental, which, alternatively, can predict in part its visual outcomes and also their limitations. Although EDOF IOLs allow relative spectacle independence, their results are more variable concerning near vision performance than the current multifocal lens designs and some of the models also require a neuroadaptation process similar to multifocal IOLs. The tolerance to high levels of induced aberrations, causing a bad quality of retinal image following implantation may significantly contribute to patient dissatisfaction after surgery with some models of EDOF IOL and may lead even to IOL explantation and exchange. In this chapter, we review the currently available generic types of EDOF IOLs, classifying them by the optical principles on which their EDOF effect is based and by their expected outcomes, trying to clarify the confusion that exists around this topic to further understand the clinical applications of the different models available.