Optimizing radiation dose while preserving the image quality is essential in CT imaging of complex anatomical structures like temporal bone and lumbar spine. This study compares single-shot volume scan mode (VCT) with conventional helical scan mode (HCT) in reducing radiation dose and preserving image quality in both temporal bone and lumbar spine CT examinations. Dose Length Product (DLP) and effective dose (E103) were analyzed and image quality was assessed by two radiologists using multiplanar reconstructions (MPR) of various anatomical structures. 80 temporal bone and 130 lumbar spine patients were scanned on either VCT or HCT. Results indicated that VCT in temporal bone lowered the radiation dose significantly by 60.5% (mean E103: 0.2 ± 0.02 mSv for VCT vs. 0.5 ± 0.06 mSv for HCT) with no significant differences in image noise or image quality. For lumbar spine CT, a 54.8% dose reduction (mean E103: 2.8 ± 1 mSv for VCT vs. 6.2 ± 2 mSv for HCT) was seen with VCT, without significant differences in image quality. Both studies bring to light the capability of VCT to lower radiation exposure without compromising the image quality. This indicates that VCT is a viable alternative to HCT for safer imaging of complicated anatomical organs.