The low water solubility of many drugs represents a major obstacle in the development of effective treatments. Nanotechnology emerges as a key tool to address this problem. Nanocarriers offer a versatile platform for encapsulating and transporting low-solubility drugs, improving their distribution in the body. This strategy not only increases the efficacy of treatments, but it also reduces the toxicity associated with conventional drugs. Mixed micelles of poloxamer and d-α-tocopherol polyethylene glycol succinate (TPGS) offer an innovative solution to improve drug solubility and biocompatibility. The combination of these polymeric surfactants allows modulating the properties of the micelle, increasing its ability to encapsulate hydrophobic compounds and improving its stability in aqueous media. This strategy not only optimizes the bioavailability of the drugs, but also presents the potential of reducing the dose needed to achieve the desired therapeutic effect, thus reducing the adverse effects associated with the treatment. In this work, mixed micelles of poloxamer and TPGS were used to improve the solubility of curcumin; different proportions of surfactants were used to prepare a series of formulations. The results showed that the hydrodynamic diameter of the micelles and the viscosity of the micellar solutions can be modulated by composition, allowing the properties of the system to be adjusted to the specific needs of each application. In addition, mixed micelles have a higher curcumin encapsulation capacity compared to systems formed by a single surfactant.