Agriculture or agriculture industry is considered one of the most sensitive to climate sector of an economy. The previous research leads to a systematic model for intercomparisons between climate and its impacts on agriculture and agricultural production. However, varied results are obtained due to the nature of input data, model approaches, and different research scenarios. These scenarios will change the equilibrium of decision-making support system and economic modeling to investigate the climate change impacts on agriculture. In Pakistan’s Real Gross Domestic Product, by “2050” climate change made a huge loss on the production of rice and wheat crops by “19.5 dollars,” with also decreased domestic private consumption. This impact not only declines the crops’ production but also has also some indirect effects on the industrial, business, and economic sectors, along with the agriculture sector of the country. These issues raise a huge number of challenges for the poor, particularly in urban areas or urban households. However, it is recommended that the government must implement a solid strategy related to agriculture that can enhance its capability to properly respond to climate change and minimize the challenges as much as possible.