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The challenges in investigating the cellular and system dynamics involved in microvascular remodeling motivates the development of models to recapitulate complex interactions. Both experimental and computational models offer biomimetic tools to incorporate, observe, and probe dynamics not always possible with in vivo methods. The objective of this chapter is to overview examples of experimental and computational modeling approaches that frame field leading research, applications, and opportunities. Major cellular players involved in microvascular growth will be introduced. Then, the need for integrative models will be emphasized by mapping challenges to the field of tissue engineering and providing specific research examples that define the range of approaches.

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Biomimetic Models for Investigation of Microvascular Remodeling

  • 章节

  • 发表日期：

    2025年

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  • Nien-Wen Hu,
  • Arinola Lampejo,
  • Ariana D. Suarez-Martinez,
  • Nicholas Hodges,
  • Mir Md Nasim Hossain,
  • Peter Balogh,
  • Bing Ren,
  • Yong Huang,
  • Jonathan J. Adorno,
  • Shashwat S. Agarwal,
  • Jacob C. Holter,
  • Elton Y. Cao,
  • Jonathan W. Song,
  • Dorothy N. Beck,
  • Shayn M. Peirce,
  • Walter L. Murfee

摘要

The challenges in investigating the cellular and system dynamics involved in microvascular remodeling motivates the development of models to recapitulate complex interactions. Both experimental and computational models offer biomimetic tools to incorporate, observe, and probe dynamics not always possible with in vivo methods. The objective of this chapter is to overview examples of experimental and computational modeling approaches that frame field leading research, applications, and opportunities. Major cellular players involved in microvascular growth will be introduced. Then, the need for integrative models will be emphasized by mapping challenges to the field of tissue engineering and providing specific research examples that define the range of approaches.