Building on Descartes’ Treatise on Man (L’Homme, 1662), Canguilhem introduces the concept of living machines. By integrating this idea with his view of life as lacking inherent vitality, as pathological and monstrous, we derive the notion of the “monstrous machine” to describe the extraordinary products of nature. This is based on Canguilhem’s application of the concept of indeterminacy, derived from the life sciences, to the physico-chemical sciences, leading to conclusions about the notion of natural undetermined or monstrous machines. He proposes the convertibility of life and technics, exploring the essence of technology within the ethnological development of man as a component of life’s technical evolution. Therefore, Canguilhem’s deconstruction of the organism in “Machine and Organism” results in a machinization of the organism, based on its multifunctionality in response to the diversity of milieu-systems and the differentiation of value-systems.