The rapid expansion of e-business in Thailand, driven by increased internet and mobile commerce usage, presents both opportunities and challenges. A key concern is the dependability and performance of e-commerce systems, particularly in handling high transaction volumes while ensuring reliability, security, and efficiency. This study examines the critical factors affecting e-business system performance in Thailand, with a focus on dependability, availability, reliability, security, latency, and throughput. To explore these challenges, this research analyzes two leading e-commerce platforms in Thailand—Shopee Thailand and Berli Jucker BJC. The study investigates how these companies manage system vulnerabilities, such as handling large-scale flash sales, mitigating cybersecurity threats, and optimizing operations in rural areas with limited infrastructure. By assessing cloud-based infrastructure, load balancing techniques, caching mechanisms, and cybersecurity measures, the research highlights strategies for enhancing system robustness. Findings from this study provide insights into improving e-commerce reliability in developing markets like Thailand, particularly in the context of digital transformation initiatives such as Thailand 4.0. The research offers practical recommendations for businesses seeking to strengthen their e-commerce platforms and ensure long-term success in a competitive digital landscape.