What Is the Pathogenesis of C. difficile Infection? What Happens at a Cellular Level and What Is the Histology of the Disease? Does the Colon Really Perforate? Is There Really Toxic Megacolon? In Some Respects, C. difficile Infection Is Similar to Nonspecific Pouchitis. Why?
摘要
Clostridioides difficile is an anaerobic, spore-forming pathogen that can cause a severe, sometimes fatal, diarrheal illness. This question explores aspects of the pathogenesis of the disease, especially the association of toxic megacolon and colonic perforation with C. difficile.