A Buschke–Lowenstein tumor is a giant condyloma acuminatum, first described in 1896 by Abraham Buschke, a Jewish German dermatologist (1868–1943) (sadly, he died in the Nazi concentration camp at Theresienstadt) [1–3]. In 1925, Buschke and his assistant Ludwig Loewenstein wrote up a case involving the penis. They described a tumor that resembled both a condyloma and a squamous cell cancer, but with unique clinical and histologic features. What came to be known as a Buschke–Lowenstein tumor is large (>10 cm) and aggressive but has benign histology and does not metastasize. However, it can be locally destructive, with malignant transformation in over 50%. Approximately two-thirds of tumors recur after resection, and mortality is estimated at 20% [4]. The tumors are related to infection with low-risk HPV subtypes 6 and 11.