This chapter adopts a systematic approach to examine the influence of mass transport, heat transfer, and chemical reaction heat on the dynamics of a single acoustic bubble. A baseline model incorporating all these phenomena was modified to create three sub-models: one excluding mass transport, another excluding heat transfer, and a third excluding the heat of chemical reactions. Comparisons between these sub-models and the baseline model highlight the individual contributions of each phenomenon. The analysis focuses on key bubble parameters, such as temperature, pressure, and radius, at the end of the first bubble collapse. Using an argon bubble as a case study, the effects of varying ambient bubble radius (R0), acoustic frequency, and pressure amplitude were explored. Excluding any of the three phenomena resulted in higher bubble temperatures relative to the baseline model. Heat transfer at the bubble interface emerged as the most critical mechanism governing the bubble’s internal energy balance, with heat dissipation significantly reducing bubble temperatures. Water vapor condensation also contributed to cooling but to a lesser degree than heat dissipation. Conversely, chemical reactions exhibited an endothermic effect, leading to a slight reduction in bubble temperature compared to mass and heat transfer processes. The dominance of each mechanism was found to depend on the acoustic frequency, pressure amplitude, and ambient bubble radius. For acoustic pressure amplitudes of 2.5 and 3 atm at frequencies of 355 and 515 kHz, respectively, mass transport became the predominant mechanism. However, at 1000 kHz, heat transfer consistently dominated across all tested amplitudes (1–3 atm). Notably, these trends were most pronounced for bubbles near their optimum ambient bubble radius, while minimal impact was observed for bubbles with ambient radii at the extremes of the studied size range.