One of the ways to increase the productivity of the copper-zinc-aluminum oxide catalyst is the influence of vibration-acoustic oscillations in situ. Thus, the aim of our work is to study of vibration-acoustic oscillations’ influence duration on the structural and morphological properties of the industrial catalyst for methanol synthesis SNM-U. The structure and surface properties of the industrial methanol synthesis catalyst trademark SNM-U before and after exposure to vibration-acoustic oscillations in situ were studied in detail by various characteristic technologies, such as X-ray diffraction and Fourier-transform infrared spectroscopy. Based on the experimental observations (XRD), a change in Cu and ZnO crystallite size is established depending on the duration of external influence on the catalyst. We showed the change of phase composition in SNM-U samples after reduction and exposure to vibration-acoustic oscillations in situ of different durations in the hydrogenation reaction of carbon oxides. It was establish by FTIR method that the intensity of some bands increases for the catalyst sample after hydrogenation working under vibration-acoustic oscillations in situ.