Monitoring water quality is crucial, as it directly impacts the health and well-being of ecosystems and the human population. The water quality parameters pH, redox potential, total dissolved solids, and competing ions are critically examined for their roles in modifying uranium chemistry within the water. As water quality parameters predominantly influence uranium mobilization in water, monitoring and understanding the influence of various water quality parameters is essential for measuring the hydrochemistry of water. The issue of uranium contamination in water (groundwater, surface water, etc.) is a concern at the global scale because of its deteriorating health effects. Notably, uranium is soluble in water, which results in both radiological and chemical toxicity in the human environment. Uranium is mobile in its oxidized state (U+6), forms at neutral to alkaline pH levels, and is facilitated by the formation of stable complex salts. Under such conditions, uranium often coexists with other similarly regulated anions and oxyanions, such as fluoride, arsenic, vanadium, and molybdenum. This chapter aims to explain the combined effect of soluble uranium in water with the interpretation of multiple water quality parameters that collectively influence its behavior and impact. Through a comprehensive literature survey of recent research and case studies, we aim to understand the complexities behind uranium mobility in water, the influence of water quality parameters, and bioavailability in aquatic environments, which is pivotal for devising effective water management strategies and mitigating the risks associated with uranium contamination. Our discussion further explores the implications of these findings for water safety monitoring and public health, highlighting the need for integrated approaches in addressing water quality issues in uranium-affected areas around the world.