Rheumatoid arthritis (RA) is an autoimmune-mediated chronic, inflammatory disease of the joints. It is degenerative, progressive, and associated with articular, extra-articular, and systemic effects. Osteoarthritis (OA) is the most common chronic musculoskeletal disorder affecting 15% of the world population. It is characterized by synovial inflammation, thin and rough articular cartilage, and reactive bone hyperplasia at the joint edge and beneath the cartilage, narrowing of joint space. The main symptom of RA and OA is pain in the joints, which increases with the duration of disease and age. There are external triggers which flare the symptoms, and during an acute phase, it is difficult to manage without painkillers. Though they give relief, it is temporary and short-lived. Though the pathogenesis and triggers and risks of OA and RA are different and both affect different joints, the pivotal molecular mechanisms involved are increased free radicals, inflammation, and joint destruction. The use of painkillers, which are beneficial for short duration, is deleterious to the health of the patients. Hence, non-pharmacological treatment is more acceptable by these patients which can help scavenge free radicals, decrease inflammation, and help in tissue repair. Maintenance of appropriate body weight, a balanced diet, and exercise will help arrest the progression of the degenerative process in the joint. Combinations of antioxidants and minerals can be given to each arthritis patient and periodic review be done to improve the quality of life.