This chapter explores the transformative impact of artificial intelligence (AI) and Big Data Analytics on nutraceutical management. As consumer demand for health-focused products such as supplements, functional foods, and herbal extracts grows, ensuring quality, safety, regulatory compliance, and personalization remains challenging. AI enhances formulation and quality assurance through predictive modeling and computer vision, while analyzing individual health data for personalized nutrition. Concurrently, Big Data leverages vast datasets from clinical trials to consumer feedback to forecast market trends, segment consumers, and guide R&D. The integration of AI and Big Data fosters deeper insights, driving innovation, safety, and tailored solutions. However, challenges like data privacy, standards, and ethics persist. Future developments may include AI-driven discovery of bioactives, real-time supply chain monitoring, and blockchain-based transparency. Embracing these innovations is essential for advancing safer, more effective, and personalized nutraceuticals that promote public health.