Cardiovascular diseases (CVDs) are the leading cause of mortality on the global level. World Health Organization (WHO) stated that an estimated 17.9 million people died from CVDs in 2019, which accounted for 32% of all global deaths. Over three quarters of CVD deaths took place in low- and middle-income countries and about two-third of hypertensive population also lives in low- and middle-income countries. In 2019 17 million premature deaths below the age of 70 were due to noncommunicable diseases out of which 38% were caused by CVDs. CVDs are a group of disorders that affect heart and blood vessels. There are various risk factors associated to it and many are modifiable in nature. There are several food items that contains medicinal compounds occurring naturally, which we call as nutraceuticals. These could be very helpful in preventing the diseases as CVDs. These nutraceuticals compounds occur in fruits, vegetables, whole grains, dairy products, nuts, oilseeds, etc. Nutraceuticals could be classified based on their source of origin as exogenous and endogenous. However, several bioactive compounds are subjected to low bioavailability and poor solubility, which leads to their inadequate absorption. This results in reduced biological activity and is considered to be a major concern for researchers. Hence, to enhance bioavailability of these compounds, the attention of researchers shifted from macroscopic to nanoscale. The efficient encapsulation of nutraceuticals by nanoformulation is beneficial in this regard. Principles of nanotechnology when incorporated increase the bioavailability of nutraceuticals, which could help prevent actions and undesirable interactions between active components of food. Hence, it helps in combating diseases like CVDs.