A range of products classified as nutraceuticals or functional foods (NFFs) are available in the open market with nutritional and pharmaceutical properties. NFFs are mostly derived from natural sources, making them to be also classified under natural products. They are distinguished from regular foods by their impact which goes beyond nutrition to include therapeutic and medicinal value. In most countries, one can purchase these products over the counter without the need for a prescription. There are however a number of countries which require stringent labeling of the packages in which these products are sold. Because the desired impact of NFFs derives from the pre-concentration extraction procedures by which they are derived from natural sources, the shelf storage and preservation technologies, and the ways in which they are formulated for administration, targeted delivery, and prolonged release, several technologies that are used for the foregoing purposes in the pharmaceutical industry are also used in the NFFs industry. This chapter describes some of the key technologies, their value proposition and rationale in the NFFs value chain – from source to delivery into the target site in the human body. Due to the diversity of approaches in this regard the chapter does not seek to be exhaustive, but to rather focus on some of the key technologies. Focusing on sol-gel, phase inversion precipitation, supercritical fluid, and microfluidic systems is meant to introduce their unique value proposition and to provide examples of research conducted in the development, optimization, and application of these four technologies which have provided important advances in the industry. The sol-gel formulation, which is based on sol-gel phase transitions, is used mainly for the parenteral administration and targeted site delivery of chemical components of NFFs. Bioactive chemical components of NFFs are most commonly administered both orally and parenterally, encapsulated or otherwise incorporated into micelles, liposomes, microcapsules, and hydrogels. Research on the development, optimization, and application of these strategies have been widely reported and will be discussed in this chapter. The chapter will also discuss phase inversion processes for NFF refinement, including membrane preparation by phase inversion techniques and release by phase inversion precipitation. To exploit the value of computational simulation and modeling studies in the optimization of the delivery and release of NFFs, many studies have been conducted aimed at the prediction of the release for more precise location of the in-vitro and in-vivo studies for the optimization of return on investment in physical and consumable resources. In this chapter, we shall discuss a selection of these studies to illustrate how this technology has come into the NFFs industry to cut costs. To further enhance delivery and prolong release of NFFs, the technology of nano-emulsions which is ubiquitously used in the pharmaceutical industry has found much use in NFFs. In this chapter, we discuss a number of permutations of the technology and the methods used in its application, including microfluidics and microfluidic devices. The chapter concludes by considering the applications of supercritical fluids in the extraction and immersion precipitation of NFFs.